Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures

被引：34

作者：

Yamamoto, H

Inoue, K

Yazaki, K

机构：

[1] Gifu Pharmaceut Univ, Dept Pharmacognosy, Gifu 5028585, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Dept Plant Gene & Totipotency, Lab Mol & Cellular Biol Totipotency, Kyoto 6068502, Japan

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 06期

关键词：

Lithospermum erythrorhizon; Boraginaceae; cell suspension cultures; caffeic acid oligomers; lithospermic acid B; (+)-rabdosiin; shikonin; secondary metabolite production;

D O I：

10.1016/S0031-9422(99)00623-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lithospermum erythrorhizon cells cultured in pigment production (M-9) medium produced lithospermic acid B, a dimerized caffeic acid ester derivative, in quantities similar to the production of shikonin. The cells also produced a related dimer, (+)-rabdosiin. In Linsmaier-Skoog liquid medium, which suppresses shikonin production, both lithospermic acid B and (+)-rabdosiin were still formed. Lithospermic acid, a caffeic acid-rosmarinic acid conjugate, was isolated as a main constituent in Lithospermum hairy root cultures. In the aerial parts of L. erythrorhizon, the content of these phenylpropanoid oligomers was relatively low compared to that of rosmarinic acid. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：651 / 657

页数：7

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