Human innate immunosenescence: causes and consequences for immunity in old age

被引：319

作者：

Panda, Alexander ^{[2
]}

Arjona, Alvaro ^{[2
]}

Sapey, Elizabeth ^{[1
]}

Bai, Fengwei ^{[2
]}

Fikrig, Erol ^{[2
]}

Montgomery, Ruth R. ^{[3
]}

Lord, Janet M. ^{[1
]}

Shaw, Albert C. ^{[2
]}

机构：

[1] Univ Birmingham, Inst Biomed Res, MRC Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

[2] Yale Univ, Infect Dis Sect, Sch Med, New Haven, CT 06520 USA

[3] Yale Univ, Rheumatol Sect, Sch Med, New Haven, CT 06520 USA

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 07期

基金：

美国国家卫生研究院;

关键词：

KILLER-CELL ACTIVITY; HUMAN NK CELLS; DENDRITIC CELLS; T-CELLS; PERIPHERAL-BLOOD; ELDERLY HUMANS; SIGNAL-TRANSDUCTION; CYTOKINE PRODUCTION; B-CELLS; CHRONIC PERIODONTITIS;

D O I：

10.1016/j.it.2009.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past decade has seen an explosion in research focusing on innate immunity. Through a wide range of mechanisms including phagocytosis, intracellular killing and activation of proinflammatory or antiviral cytokine production, the cells of the innate immune system initiate and support adaptive immunity. The effects of aging on innate immune responses remain incompletely understood, particularly in humans. Here we review advances in the study of human immunosenescence in the diverse cells of the innate immune system, including neutrophils, monocytes, macrophages, natural killer and natural killer T (NKT) cells and dendritic cells-with a focus on consequences for the response to infection or vaccination in old age.

引用

页码：325 / 333

页数：9

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