The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

被引：720

作者：

Takenawa, Tadaomi ^{[1
]}

Suetsugu, Shiro ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Biochem, Minato Ku, Tokyo 1088639, Japan

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 01期

关键词：

D O I：

10.1038/nrm2069

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Wiskott-Aldrich syndrome protein (WASP) and WASP-family verprolin-homologous protein (WAVE) family proteins are scaffolds that link upstream signals to the activation of the ARP2/3 complex, leading to a burst of actin polymerization. ARP2/3-complex-mediated actin polymerization is crucial for the reorganization of the actin cytoskeleton at the cell cortex for processes such as cell movement, vesicular trafficking and pathogen infection. Large families of membrane-binding proteins were recently found to interact with WASP and WAVE family proteins, therefore providing a new layer of membrane-dependent regulation of actin polymerization.

引用

页码：37 / 48

页数：12

共 150 条

[91] Negative regulation of yeast WASp by two SH3 domain-containing proteins [J].

Rodal, AA ;

Manning, AL ;

Goode, BL ;

Drubin, DG .

CURRENT BIOLOGY, 2003, 13 (12) :1000-1008

[92] Molecular requirements for actin-based lamella formation in Drosophila S2 cells [J].

Rogers, SL ;

Wiedemann, U ;

Stuurman, N ;

Vale, RD .

JOURNAL OF CELL BIOLOGY, 2003, 162 (06) :1079-1088

[93] Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4,5-bisphosphate [J].

Rohatgi, R ;

Ho, HYH ;

Kirschner, MW .

JOURNAL OF CELL BIOLOGY, 2000, 150 (06) :1299-1309

[94] The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly [J].

Rohatgi, R ;

Ma, L ;

Miki, H ;

Lopez, M ;

Kirchhausen, T ;

Takenawa, T ;

Kirschner, MW .

CELL, 1999, 97 (02) :221-231

[95] Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway [J].

Rohatgi, R ;

Nollau, P ;

Ho, HYH ;

Kirschner, MW ;

Mayer, BJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :26448-26452

[96] Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3 [J].

Rozelle, AL ;

Machesky, LM ;

Yamamoto, M ;

Driessens, MHE ;

Insall, RH ;

Roth, MG ;

Luby-Phelps, K ;

Marriott, G ;

Hall, A ;

Yin, HL .

CURRENT BIOLOGY, 2000, 10 (06) :311-320

[97] Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation [J].

Sasahara, Y ;

Rachid, R ;

Byrne, MJ ;

de la Fuente, MA ;

Abraham, RT ;

Ramesh, N ;

Geha, RS .

MOLECULAR CELL, 2002, 10 (06) :1269-1281

[98] Caenorhabditis elegans WASP-interacting protein homologue WIP-1 is involved in morphogenesis through maintenance of WSP-1 protein levels [J].

Sawa, M ;

Takenawa, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 340 (02) :709-717

[99] Essential role of the C-elegans Arp2/3 complex in cell migration during ventral enclosure [J].

Sawa, M ;

Suetsugu, S ;

Sugimoto, A ;

Miki, H ;

Yamamoto, M ;

Takenawa, T .

JOURNAL OF CELL SCIENCE, 2003, 116 (08) :1505-1518

[100] Dynamin2 and cortactin regulate actin assembly and filament organization [J].

Schafer, DA ;

Weed, SA ;

Binns, D ;

Karginov, AV ;

Parsons, JT ;

Cooper, JA .

CURRENT BIOLOGY, 2002, 12 (21) :1852-1857

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