Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients

被引：20

作者：

Shapiro, J

Belmaker, RH

Biegon, A

Seker, A

Agam, G

机构：

[1] Stanley Ctr Bipolar Res, Beer Sheva, Israel

[2] Minist Hlth Mental Hlth Ctr, Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Dept Clin Biochem, IL-84105 Beer Sheva, Israel

[4] Ben Gurion Univ Negev, Fac Hlth Sci, IL-84105 Beer Sheva, Israel

来源：

JOURNAL OF NEURAL TRANSMISSION | 2000年 / 107卷 / 05期

关键词：

myo-inositol; scyllo-inositol; post-mortem brain; bipolar patients; unipolar patients; schizophrenic patients; neuroleptic treatment; suicide victims;

D O I：

10.1007/s007020070081

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Inositol levels measured in postmortem brain of unipolar, bipolar and schizophrenic patients, suicide victims and normal controls showed no difference in scyllo-inositol levels in frontal or occipital cortex between any of the groups. We could not replicate previous reports of low myo-inositol levels in the frontal cortex of unipolar, bipolar and schizophrenic patients and suicide victims. There was no correlation between myo-inositol levels and estimated chlorpromazine equivalents in neuroleptic-treated subjects, and no effect of chronic haloperidol treatment on rat brain myo-inositol levels.

引用

页码：603 / 607

页数：5

共 14 条

[1] Myo-inositol in depressive and healthy subjects determined by frontal 1H-magnetic resonance spectroscopy at 1.5 tesla [J].