MECHANISMS OF DISEASE Cell Death

被引：938

作者：

Hotchkiss, Richard S. ^{[1
,2
,3
]}

Strasser, Andreas ^{[4
]}

McDunn, Jonathan E. ^{[1
]}

Swanson, Paul E. ^{[5
]}

机构：

[1] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA

[4] Walter & Eliza Hall Inst Med Res, Dept Mol Genet Canc, Melbourne, Vic 3050, Australia

[5] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2009年 / 361卷 / 16期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

BH3-ONLY PROTEINS PUMA; TUMOR NECROSIS FACTOR; INDUCED APOPTOSIS; CANCER-THERAPY; CYTOCHROME-C; PHARMACOLOGICAL MANIPULATION; MEMBRANE PERMEABILIZATION; AUTOREACTIVE THYMOCYTES; CEREBRAL-ISCHEMIA; ADOPTIVE TRANSFER;

D O I：

10.1056/NEJMra0901217

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy. Copyright © 2009 Massachusetts Medical Society.

引用

页码：1570 / 1583

页数：14

共 128 条

[1] Bcl-2-regulated apoptosis: mechanism and therapeutic potential [J].

Adams, Jerry M. ;

Cory, Suzanne .

CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (05) :488-496

[2] Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers [J].

Ahn, Chang Hyeok ;

Jeong, Eun Goo ;

Lee, Jong Woo ;

Kim, Min Sung ;

Kim, Sung Hee ;

Kim, Sung Soo ;

Yoo, Nam Jin ;

Lee, Sug Hyung .

APMIS, 2007, 115 (12) :1344-1349

[3] The roles of therapy-induced autophagy and necrosis in cancer treatment [J].

Amaravadi, Ravi K. ;

Thompson, Craig B. .

CLINICAL CANCER RESEARCH, 2007, 13 (24) :7271-7279

[4]

[Anonymous], SCI STKE

[5] CYTOPLASMIC COMPONENTS IN HEPATIC CELL LYSOSOMES [J].

ASHFORD, TP ;

PORTER, KR .

JOURNAL OF CELL BIOLOGY, 1962, 12 (01) :198-&

[6] Apoptosis in sepsis: Mechanisms, clinical impact and potential therapeutic targets [J].

Ayala, Alfred ;

Perl, Mario ;

Venet, Fabienne ;

Lomas-Neira, Joanne ;

Swan, Ryan ;

Chung, Chun-Shiang .

CURRENT PHARMACEUTICAL DESIGN, 2008, 14 (19) :1853-1859

[7] Neurobiology - A new clue to how alcohol damages brains [J].

Barinaga, M .

SCIENCE, 2000, 287 (5455) :947-948

[8] Clearing the Brain's cobwebs: The role of autophagy in neuroprotection [J].

Bossy, Blaise ;

Perkins, Guy ;

Bossy-Wetzel, Ella .

CURRENT NEUROPHARMACOLOGY, 2008, 6 (02) :97-101

[9] Mitochondria: pharmacological manipulation of cell death [J].

Bouchier-Hayes, L ;

Lartigue, L ;

Newmeyer, DD .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (10) :2640-2647

[10] Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity [J].

Bouillet, P ;

Metcalf, D ;

Huang, DCS ;

Tarlinton, DM ;

Kay, TWH ;

Köntgen, F ;

Adams, JM ;

Strasser, A .

SCIENCE, 1999, 286 (5445) :1735-1738

← 1 2 3 4 5 6 7 8 9 10 →