CD14 signalling in lipid rafts:: new ligands and co-receptors

被引:96
作者
Schmitz, G [1 ]
Orsó, E [1 ]
机构
[1] Univ Regensburg, Inst Clin Chem & Lab Med, D-93053 Regensburg, Germany
关键词
CD14-dependent receptor cluster; raft-heterogeneity; LPS-mediated signalling; atherogenesis; innate immunity; mononuclear phagocytes;
D O I
10.1097/00041433-200210000-00007
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Purpose of review Lipid rafts on monocytes/macrophages provide a dynamic microenvironment for an integrated lipopolysaccharide receptor (CD14)-dependent clustering of a set of receptors involved in innate immunity and clearance of atherogenic lipoproteins. The purpose of this review is to summarize the recent advances in our understanding of CD14-dependent receptor clustering and its relevance in atherogenesis. Recent findings Upon binding of various ligands, CD14 as a multiligand pattern recognition receptor induces specific coassembly of additional receptors present on circulating monocytes. Summary The composition of the receptor cluster and thus the associated signalling pathways defines a ligand specific cellular response, linking endogenous and exogenous host defense to a common recognition platform in rafts.
引用
收藏
页码:513 / 521
页数:9
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