Bioactive NiTi shape memory alloy used as bone bonding implants

被引:105
作者
Chen, MF
Yang, XJ [1 ]
Hu, RX
Cui, ZD
Man, HC
机构
[1] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China
[2] Tianjin Univ Technol, Dept Mat Sci & Engn, Tianjin 300191, Peoples R China
[3] Hong Kong Polytech Univ, Dept Ind & Syst Engn, Adv Mfg Technol Res Ctr, Kowloon, Hong Kong, Peoples R China
来源
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2004年 / 24卷 / 04期
基金
中国国家自然科学基金;
关键词
bioactive NiTi alloy; hydroxyapatite layer; implants; bone bonding; interface;
D O I
10.1016/j.msec.2003.11.001
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The aim of this study is to convert the bio-inert NiTi surface into a bioactive one and to evaluate its biocompatibility and bone integration in vivo. To make a bioactive layer on the surface of NiTi, the alloy was immersed in HNO3 and in NaOH aqueous solution in turn, and then soaked in simulated body fluid (SBF) for 48 h. Ca- and P-rich layer was observed using environmental scanning electron microscope (ESEM) and energy-dispersion X-ray Spectroscopy (EDS). Furthermore, X-ray diffraction (XRD) spectrum confirmed that this layer is hydroxyapatite (HA). The coated and uncoated cylindrical implants were bilaterally implanted into the femurs of rabbits. At 6 and 13 weeks after implantation, the interfaces between the bone and the implant were evaluated by undecalcified histological examination under light and fluorescent microscope as well as ESEM. The results show that osteoblasts actively proliferated on the HA coating at 6 weeks after implantation. After 13 weeks, a large amount of new bone directly in contact with the host bone was observed. The interface is intact. In contrary, the uncoated implant-bone interface has gaps and fibrous layer was observed. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:497 / 502
页数:6
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