Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE

被引：42

作者：

Paden, C. R. ^{[1
,2
]}

Yusof, M. F. B. M. ^{[3
]}

Al Hammadi, Z. M. ^{[3
]}

Queen, K. ^{[1
,2
]}

Tao, Y. ^{[1
]}

Eltahir, Y. M. ^{[3
]}

Elsayed, E. A. ^{[3
]}

Marzoug, B. A. ^{[3
]}

Bensalah, O. K. A. ^{[3
]}

Khalafalla, A. I. ^{[3
]}

Al Mulla, M. ^{[4
]}

Khudhair, A. ^{[4
]}

Elkheir, K. A. ^{[4
]}

Issa, Z. B. ^{[4
]}

Pradeep, K. ^{[4
]}

Elsaleh, F. N. ^{[4
]}

Imambaccus, H. ^{[5
]}

Sasse, J. ^{[5
]}

Weber, S. ^{[5
]}

Shi, M. ^{[6
]}

Zhang, J. ^{[1
]}

Li, Y. ^{[1
]}

Pham, H. ^{[1
]}

Kim, L. ^{[1
]}

Hall, A. J. ^{[1
]}

Gerber, S. I. ^{[1
]}

Al Hosani, F. I. ^{[4
]}

Tong, S. ^{[1
]}

Al Muhairi, S. S. M. ^{[3
]}

机构：

[1] Ctr Dis Control & Prevent, Div Viral Dis, Atlanta, GA USA

[2] Oak Ridge Inst Sci Educ, Oak Ridge, TN USA

[3] Abu Dhabi Food Control Author, Abu Dhabi, U Arab Emirates

[4] Hlth Author Abu Dhabi, Abu Dhabi, U Arab Emirates

[5] Sheikh Khalifa Med City, Abu Dhabi, U Arab Emirates

[6] Univ Sydney, Sydney, NSW, Australia

来源：

ZOONOSES AND PUBLIC HEALTH | 2018年 / 65卷 / 03期

关键词：

dromedary camel; epidemiology; genomics; middle east respiratory syndrome; viral pathogens; zoonoses; MERS-COV INFECTION; DROMEDARY CAMELS; SAUDI-ARABIA; ANTIBODIES; OUTBREAK; EVOLUTION; EXPOSURE; JEDDAH; OMAN;

D O I：

10.1111/zph.12435

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Since the emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, there have been a number of clusters of human-to-human transmission. These cases of human-to-human transmission involve close contact and have occurred primarily in healthcare settings, and they are suspected to result from repeated zoonotic introductions. In this study, we sequenced whole MERS-CoV genomes directly from respiratory samples collected from 23 confirmed MERS cases in the United Arab Emirates (UAE). These samples included cases from three nosocomial and three household clusters. The sequences were analysed for changes and relatedness with regard to the collected epidemiological data and other available MERS-CoV genomic data. Sequence analysis supports the epidemiological data within the clusters, and further, suggests that these clusters emerged independently. To understand how and when these clusters emerged, respiratory samples were taken from dromedary camels, a known host of MERS-CoV, in the same geographic regions as the human clusters. Middle East respiratory syndrome coronavirus genomes from six virus-positive animals were sequenced, and these genomes were nearly identical to those found in human patients from corresponding regions. These data demonstrate a genetic link for each of these clusters to a camel and support the hypothesis that human MERS-CoV diversity results from multiple zoonotic introductions.

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页码：322 / 333

页数：12

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