The role of dendritic cells in selection of classical and nonclassical CD8+ T cells in vivo

被引:20
作者
Cannarile, MA
Decanis, N
van Meerwijk, JPM
Brocker, T
机构
[1] Univ Munich, Inst Immunol, D-80336 Munich, Germany
[2] INSERM, Tolerance & Autoimmun Sect, Unite 563, Toulouse, France
关键词
D O I
10.4049/jimmunol.173.8.4799
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T cell development is determined by positive and negative selection events. An intriguing question is how signals through the TCR can induce thymocyte survival and maturation in some and programmed cell death in other thymocytes. This paradox can be explained by the hypothesis that different thymic cell types expressing self-MHC/peptide ligands mediate either positive or negative selection events. Using transgenic mice that express MHC class I (MHC-I) selectively on DC, we demonstrate a compartmentalization of thymic functions and reveal that DC induce CTL tolerance to MHC-I-positive hemopoietic targets in vivo. However, in normal and bone marrow chimeric mice, MHC-I+ DC are sufficient to positively select neither MHC-Ib (H2-M3)- nor MHC-Ia (H2-K)-restricted CD8(+) T cells. Thus, thymic DC are specialized in tolerance induction, but cannot positively select the vast majority of MHC-I-restricted CD8(+) T cells.
引用
收藏
页码:4799 / 4805
页数:7
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