Monte Carlo simulation in PET and SPECT instrumentation using GATE

被引:73
作者
Assié, K
Breton, V
Buvat, I
Comtat, C
Jan, S
Krieguer, M
Lazaro, D
Morel, C [1 ]
Rey, M
Santin, G
Simon, L
Staelens, S
Strul, D
Vieira, JM
Van de Walle, R
机构
[1] Univ Lausanne, Inst High Energy Phys, CH-1015 Lausanne, Switzerland
[2] CHU Pitie Salpetriere, INSERM, U494, F-75634 Paris 13, France
[3] Univ Clermont Ferrand, Phys Corpusculaire Lab, F-63177 Clermont Ferrand, France
[4] CEA, Serv Hosp Frederic Joliot, F-91401 Orsay, France
[5] Free Univ Brussels, Inter Univ Inst High Energies, B-1050 Brussels, Belgium
[6] Univ Ghent, ELIS Dept, B-9000 Ghent, Belgium
关键词
Monte Carlo simulation; nuclear medicine; emission tomography; GATE; PET; SPECT;
D O I
10.1016/j.nima.2004.03.117
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Monte Carlo simulation is an essential toot to assist in the design of new medical imaging devices for emission tomography. On one hand, dedicated Monte Carlo codes have been developed for PET and SPECT. However, they suffer from a variety of drawbacks and limitations in terms of validation, accuracy, and/or support. On the other hand, accurate and versatile simulation codes such as GEANT3, EGS4, MCNP, and recently GEANT4 have been written for high energy physics. They all include well-validated physics models, geometry modeling tools and efficient visualization utilities. Nevertheless these packages are quite complex and necessitate a steep learning curve. GATE, the GEANT4 Application for Tomographic Emission, encapsulates the GEANT4 libraries in order to achieve a modular, versatile, scripted simulation toolkit adapted to the field of nuclear medicine. In particular, GATE allows the users to describe time-dependent phenomena such as detector movements or source decay kinetics, thus allowing to simulate time curves under realistic acquisition conditions. At present, it is being further developed and validated within the OpenGATE Collaboration. We give a succinct overview of GATE and four examples of its validation against real data obtained with PET and SPECT cameras. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:180 / 189
页数:10
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