Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications

被引:586
作者
Qiao, Ruirui [1 ]
Yang, Chunhui [1 ]
Gao, Mingyuan [1 ]
机构
[1] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
关键词
INTRAVASCULAR CONTRAST AGENT; MAGNETIC-RESONANCE ANGIOGRAPHY; BLOOD-POOL AGENT; ONE-POT REACTION; TAT PEPTIDE; FOLATE RECEPTOR; CELLULAR UPTAKE; ORGANIC-MATTER; SURFACE CHARACTERISTICS; NC100150; INJECTION;
D O I
10.1039/b902394a
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Superparamagnetic iron oxide nanoparticles have received great attention due to their applications as contrast agents for magnetic resonance imaging (MRI). This feature article briefly introduces the concepts of MRI and MRI contrast agents, and then mainly discusses the synthesis, surface modification, surface functionalization, colloidal stability and biocompatibility of iron oxide particles, followed by their MRI applications.
引用
收藏
页码:6274 / 6293
页数:20
相关论文
共 193 条
[1]   Sonochemical synthesis of stable hydrosol of Fe3O4 nanoparticles [J].
Abu Mukh-Qasem, R ;
Gedanken, A .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2005, 284 (02) :489-494
[2]   Pulmonary MR angiography with ultrasmall superparamagnetic iron oxide particles as a blood pool agent and a navigator echo for respiratory gating:: Pilot study [J].
Ahlström, KH ;
Johansson, LO ;
Rodenburg, JB ;
Ragnarsson, AS ;
Åkeson, P ;
Börseth, A .
RADIOLOGY, 1999, 211 (03) :865-869
[3]   Critical sizes in the growth of Au clusters [J].
Alvarez, MM ;
Khoury, JT ;
Schaaff, TG ;
Shafigullin, M ;
Vezmar, I ;
Whetten, RL .
CHEMICAL PHYSICS LETTERS, 1997, 266 (1-2) :91-98
[4]   The role of inflammation and cytokines in brain injury [J].
Arvin, B ;
Neville, LF ;
Barone, FC ;
Feuerstein, GZ .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1996, 20 (03) :445-452
[5]   VALUE OF HEPATIC IRON MEASUREMENTS IN EARLY HEMOCHROMATOSIS AND DETERMINATION OF THE CRITICAL IRON LEVEL ASSOCIATED WITH FIBROSIS [J].
BASSETT, ML ;
HALLIDAY, JW ;
POWELL, LW .
HEPATOLOGY, 1986, 6 (01) :24-29
[6]  
BATE G, 1980, FERROMAGNETIC MAT, V2, P439
[7]   SYNTHESIS OF VERY FINE MAGHEMITE PARTICLES [J].
BEE, A ;
MASSART, R ;
NEVEU, S .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1995, 149 (1-2) :6-9
[8]   Synthesis and structure of the nanoclusters [Hg32Se14(SePh)(36)], [Cd32Se14(SePh)(36-)(PPh(3))(4)], [P(Et)(2)(Ph)C(4)H(8)OSiMe(3)](5-)[Cd18I17(PSiMe(3))(12)], and [N(Et)(3)C(4)H(8)OSiMe(3)](5)[Cd18I17(PSiMe(3))(12)] [J].
Behrens, S ;
Bettenhausen, M ;
Deveson, AC ;
Eichhofer, A ;
Fenske, D ;
Lohde, A ;
Woggon, U .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (19) :2215-2218
[9]   Iron oxide-enhanced MR lymphography: initial experience [J].
Bellin, MF ;
Beigelman, C ;
Precetti-Morel, S .
EUROPEAN JOURNAL OF RADIOLOGY, 2000, 34 (03) :257-264
[10]   Syngeneic fibroblasts transfected with a plasmid encoding interleukin-4 as non-viral vectors for anti-inflammatory gene therapy in collagen-induced arthritis [J].
Bessis, N ;
Cottard, V ;
Saidenberg-Kermanach, N ;
Lemeiter, D ;
Fournier, C ;
Boissier, MC .
JOURNAL OF GENE MEDICINE, 2002, 4 (03) :300-307