Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase

被引：9

作者：

Bello, CG

Harris, JM

Manthey, MK

Coggins, JR

Abell, C

机构：

[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England

[2] Univ Glasgow, Dept Biochem, Glasgow G12 8QQ, Lanark, Scotland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0960-894X(00)00057-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mechanistic differences between type I and type II dehydroquinases have been exploited in the design of type specific inhibitors. (2R)-2-Bromo-3-dehydroquinic acid (3), (2R)-2-fluoro-3-dehydroquinic acid (5) and 2-bromo-3-dehydroshikimic acid (4), all excellent substrates for type II dehydroquinase, are shown to be irreversible inhibitors of type I dehydroquinase. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：407 / 409

页数：3

共 13 条

[11] Synthesis of (2R)-2-bromodehydroquinic acid and (2R)-2-fluorodehydroquinic acid [J].