Occurrence and behaviour of 105 active pharmaceutical ingredients in sewage waters of a municipal sewer collection system

被引：180

作者：

Lindberg, Richard H. ^{[1
]}

Ostman, Marcus ^{[1
]}

Olofsson, Ulrika ^{[2
]}

Grabic, Roman ^{[3
]}

Fick, Jerker ^{[1
]}

机构：

[1] Umea Univ, Dept Chem, S-90187 Umea, Sweden

[2] Umeva, Umea, Sweden

[3] Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, South Bohemian Res Ctr Aquaculture & Biodiuers Hy, Vodnany 38925, Czech Republic

来源：

WATER RESEARCH | 2014年 / 58卷

关键词：

Active pharmaceutical ingredients; Municipal sewage waters; Online SPE-LC-MS/MS; Behaviour; Mass flows; SOLID-PHASE EXTRACTION; FLUOROQUINOLONE ANTIBACTERIAL AGENTS; TANDEM MASS-SPECTROMETRY; URBAN WASTE-WATER; LIQUID-CHROMATOGRAPHY; ORGANIC CONTAMINANTS; SUBSTANCES; REMOVAL; SURFACE; TRENDS;

D O I：

10.1016/j.watres.2014.03.076

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The concentrations and behaviour of 105 different active pharmaceutical ingredients (APIs) in the aqueous phase of sewage water within a municipal sewer collection system have been investigated. Sewage water samples were gathered from seven pump stations (one of which was located within a university hospital) and from sewage water treatment influent and effluent. The targeted APIs were quantified using a multi-residue method based on online solid phase extraction liquid chromatography tandem mass spectrometry. The method was thoroughly validated and complies with EU regulations on sample handling, limits of quantification, quality control and selectivity. 51 APIs, including antibiotics, antidepressants, hypertension drugs, analgesics, NSAIDs and psycholeptics, were found frequently within the sewer collection system. API concentrations and mass flows were evaluated in terms of their frequency of detection, daily variation, median/minimum/maximum/average concentrations, demographic dissimilarities, removal efficiencies, and mass flow profiles relative to municipal sales data. Our results suggest that some APIs are removed from, or introduced to, the aqueous phase of sewage waters within the studied municipal collection system. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：221 / 229

页数：9

共 32 条

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