Septins and the Lateral Compartmentalization of Eukaryotic Membranes

被引：237

作者：

Caudron, Fabrice ^{[1
]}

Barral, Yves ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Dept Biol, Inst Biochem, CH-8093 Zurich, Switzerland

来源：

DEVELOPMENTAL CELL | 2009年 / 16卷 / 04期

关键词：

MESSENGER-RNA TRANSPORT; SACCHAROMYCES-CEREVISIAE; PLASMA-MEMBRANE; DENDRITIC SPINES; DIFFUSION BARRIER; BUDDING YEAST; CELL POLARITY; ENDOPLASMIC-RETICULUM; MAMMALIAN SEPTIN; TIGHT JUNCTIONS;

D O I：

10.1016/j.devcel.2009.04.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic cells from neurons and epithelial cells to unicellular fungi frequently rely on cellular appendages such as axons, dendritic spines, cilia, and buds for their biology. The emergence and differentiation of these appendages depend on the formation of lateral diffusion barriers at their bases to insulate their membranes from the rest of the cell. Here, we review recent progress regarding the molecular mechanisms and functions of such barriers. This overview underlines the importance and conservation of septin-dependent diffusion barriers, which coordinately compartmentalize both plasmatic and internal membranes. We discuss their role in memory establishment and the control of cellular aging.

引用

页码：493 / 506

页数：14

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