A simple and efficient new approach to the total synthesis of (+/-)-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN)

被引：14

作者：

Coelho, F

deAzevedo, MBM

Boschiero, R

Resende, P

机构：

[1] UNICAMP, Instituto de Química, Depto. de Quim. Orgânica, 13083-970 - Campinas, SP

来源：

SYNTHETIC COMMUNICATIONS | 1997年 / 27卷 / 14期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1080/00397919708004109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on the utilization of a [2+2] cycloaddition reaction between dichloroketene and an appropriated olefin as a key step, we describe a new and simple four step approach to the total synthesis of (+/-)-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN), a selective GABA(B) agonist used as antispastic agent.

引用

页码：2455 / 2465

页数：11

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