Porphyrin-DNA cross-linking agent hybrids: chemical synthesis and biological studies

被引:20
作者
He, HP
Tian, T
Wang, P
Wu, L
Xu, JJ
Zhou, X [1 ]
Zhang, XL
Cao, XP
Wu, XJ
机构
[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
[2] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
[3] Wuhan Univ, Coll Med, Wuhan 430072, Peoples R China
[4] Lanzhou Univ, Natl Appl Organ Chem, Lanzhou 730000, Peoples R China
基金
中国国家自然科学基金;
关键词
photocleavage; DNA cross-linking; anti-tumor agent;
D O I
10.1016/j.bmcl.2004.04.044
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Three new porphyrin-DNA cross-linking conjugates 8, 9, and 10 have been synthesized. Their photoinduced DNA cleavage activity have been studied. The IC50 Values to THP-1 cells in the presence of porphyrin derivatives 8, 9, and 10 with photo irradiation were 5.6, 88.4, and 61.8 nM, respectively. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:3013 / 3016
页数:4
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