Regulatory T cells

被引：188

作者：

Beissert, Stefan

Schwarz, Agatha

Schwarz, Thomas

机构：

[1] Univ Kiel, Dept Dermatol, D-24105 Kiel, Germany

[2] Univ Munster, Dept Dermatol, D-4400 Munster, Germany

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2006年 / 126卷 / 01期

关键词：

D O I：

10.1038/sj.jid.5700004

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described. Naturally occurring CD4(+) CD25(+) Tregs are important in the prevention of autoimmune diseases. Type 1 Tregs, another subtype of Treg that is inducible, exert their suppressive activity primarily via the release of IL-10. Detailed knowledge about the phenotype and mode of action of these cells will significantly increase our understanding of the pathogenesis of autoimmune diseases and will also help to identify new therapeutic strategies.

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页码：15 / 24

页数：10

相关论文

共 87 条

[1]

Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745

[2] CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 [J].

Annacker, O ;

Pimenta-Araujo, R ;

Burlen-Defranoux, O ;

Barbosa, TC ;

Cumano, A ;

Bandeira, A .

JOURNAL OF IMMUNOLOGY, 2001, 166 (05) :3008-3018

[3] Involvement of dectin-2 in ultraviolet radiation-induced tolerance [J].

Aragane, Y ;

Maeda, A ;

Schwarz, A ;

Tezuka, T ;

Ariizumi, K ;

Schwarz, T .

JOURNAL OF IMMUNOLOGY, 2003, 171 (07) :3801-3807

[4] Mechanisms involved in ultraviolet light-induced immunosuppression [J].

Beissert, S ;

Schwarz, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 1999, 4 (01) :61-64

[5] The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].

Bennett, CL ;

Christie, J ;

Ramsdell, F ;

Brunkow, ME ;

Ferguson, PJ ;

Whitesell, L ;

Kelly, TE ;

Saulsbury, FT ;

Chance, PF ;

Ochs, HD .

NATURE GENETICS, 2001, 27 (01) :20-21

[6] Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4+25+ immunoregulatory T cells [J].

Bensinger, SJ ;

Bandeira, A ;

Jordan, MS ;

Caton, AJ ;

Laufer, TM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (04) :427-438

[7] Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells [J].

Berger, CL ;

Tigelaar, R ;

Cohen, J ;

Mariwalla, K ;

Trinh, J ;

Wang, NC ;

Edelson, RL .

BLOOD, 2005, 105 (04) :1640-1647

[8] NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells [J].

Bopp, T ;

Palmetshofer, A ;

Serfling, E ;

Heib, V ;

Schmitt, S ;

Richter, C ;

Klein, M ;

Schild, H ;

Schmitt, E ;

Stassen, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :181-187

[9] Neuropilin-1: a surface marker of regulatory T cells [J].

Bruder, D ;

Probst-Kepper, M ;

Westendorf, AM ;

Geffers, R ;

Beissert, S ;

Loser, K ;

von Boehmer, H ;

Buer, J ;

Hansen, W .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (03) :623-630

[10] Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse [J].

Brunkow, ME ;

Jeffery, EW ;

Hjerrild, KA ;

Paeper, B ;

Clark, LB ;

Yasayko, SA ;

Wilkinson, JE ;

Galas, D ;

Ziegler, SF ;

Ramsdell, F .

NATURE GENETICS, 2001, 27 (01) :68-73

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