Enzymatic C-C bond-forming reactions in organic synthesis

被引：50

作者：

Seoane, G ^{[1
]}

机构：

[1] Univ Republica, Fac Quim, Dept Quim Organ, Montevideo, Uruguay

来源：

CURRENT ORGANIC CHEMISTRY | 2000年 / 4卷 / 03期

关键词：

D O I：

10.2174/1385272003376283

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Even though the use of enzymes as catalyst in synthetic organic chemistry is widespread, their application in C-C- bond-forming reactions is still poor. There are several types of enzymes that catalyze C-C bond formation and the most used are the most readily available. Currently, the availability of these enzymes is increasing. This review will cover synthetic applications of three types of enzymes related to three different reactions: aldol reaction, acyloin condensation, and cyanohydrin reaction. The enzymes involved, aldolases, pyruvate decarboxylase and oxynitrilases, are all readily available.

引用

页码：283 / 304

页数：22

共 216 条

[41] CONFIGURATION OF SUBSTRATE AND PRODUCTS OF N-ACETYLNEURAMINATE PYRUVATE-LYASE FROM CLOSTRIDIUM-PERFRINGENS [J].

DEIJL, CM ;

VLIEGENTHART, JFG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 111 (02) :668-674

[42] ENZYMES AS REAGENTS IN ORGANIC-CHEMISTRY - TRANSKETOLASE-CATALYZED SYNTHESIS OF D-[1,2-(C-13)2]XYLULOSE [J].

DEMUYNCK, C ;

BOLTE, J ;

HECQUET, L ;

SAMAKI, H .

CARBOHYDRATE RESEARCH, 1990, 206 (01) :79-85

[43] ENZYME-CATALYZED SYNTHESIS OF CARBOHYDRATES - SYNTHETIC POTENTIAL OF TRANSKETOLASE [J].

DEMUYNCK, C ;

BOLTE, J ;

HECQUET, L ;

DALMAS, V .

TETRAHEDRON LETTERS, 1991, 32 (38) :5085-5088

[44]

Drauz K., 1995, ENZYME CATALYSIS ORG

[45] REVERSIBLE AND INSITU FORMATION OF ORGANIC ARSENATES AND VANADATES AS ORGANIC PHOSPHATE MIMICS IN ENZYMATIC-REACTIONS - MECHANISTIC INVESTIGATION OF ALDOL REACTIONS AND SYNTHETIC APPLICATIONS [J].

DRUECKHAMMER, DG ;

DURRWACHTER, JR ;

PEDERSON, RL ;

CRANS, DC ;

DANIELS, L ;

WONG, CH .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (01) :70-77

[46] Asymmetric synthesis of tetronic acids by Blaise reaction of protected optically active cyanohydrins [J].

Duffield, JJ ;

Regan, AC .

TETRAHEDRON-ASYMMETRY, 1996, 7 (03) :663-666

[47] ENZYMATIC ALDOL CONDENSATION ISOMERIZATION AS A ROUTE TO UNUSUAL SUGAR-DERIVATIVES [J].

DURRWACHTER, JR ;

DRUECKHAMMER, DG ;

NOZAKI, K ;

SWEERS, HM ;

WONG, CH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (24) :7812-7818

[48] FRUCTOSE 1,6-DIPHOSPHATE ALDOLASE CATALYZED STEREOSELECTIVE SYNTHESIS OF C-ALKYL AND N-CONTAINING SUGARS - THERMODYNAMICALLY CONTROLLED C-C BOND FORMATIONS [J].

DURRWACHTER, JR ;

WONG, CH .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (18) :4175-4181

[49]

EFFENBERGER F, 1994, ANGEW CHEM INT EDIT, V33, P1555, DOI 10.1002/anie.199415551

[50] ENZYME-CATALYZED CYANOHYDRIN SYNTHESIS IN ORGANIC-SOLVENTS [J].

EFFENBERGER, F ;

ZIEGLER, T ;

FORSTER, S .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1987, 26 (05) :458-460

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