Synthesis of optically active 2,2-difluorohomoallylalcohols by lipase-catalyzed transesterification

被引：12

作者：

Kirihara, M

Kawasaki, M

Katsumata, H

Kakuda, H

Shiro, M

Kawabata, S

机构：

[1] Shizuoka Inst Sci & Technol, Dept Mat Sci, Shizuoka 4378555, Japan

[2] Toyama Prefectural Univ, Fac Engn, Toyama 9390398, Japan

[3] Toyama Med & Pharmaceut Univ, Chem Lab, Sugitani, Toyama 9300194, Japan

[4] Rigaku Corp, Akishima, Tokyo 1968666, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(02)00612-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Racemic 2,2-difluorohotnoallylalcohols could be resolved into (R)-alcohols and (S)-acetates through Pseudomonas fluorescens lipase-catalyzed enantioselective transesterification. The utility of the resulting chiral, non-racemic 2,2-difluorohomoallylalcohols was demonstrated by conversion of one of the (S)-acetates into a synthetically important 2,2-difluoro-3-hydroxycarboxylate derivative. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2283 / 2289

页数：7

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