Analytical applications of single-molecule detection

被引：47

作者：

Keller, RA

Ambrose, WP

Arias, AA

Gai, H

Emory, SR

Goodwin, PM

Jett, JH

机构：

[1] Los Alamos Natl. Laboratory (LANL), Los Alamos, NM, United States

来源：

ANALYTICAL CHEMISTRY | 2002年 / 74卷 / 11期

关键词：

D O I：

10.1021/ac022035i

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Here's another example of where less is really more. Richard Keller, W. Patrick Ambrose, Angela Arias, Hong Cai, Steven Emory, Peter Goodwin, and James Jett at Los Alamos National Laboratory describe the advantages of measuring just one fluorescent molecule instead of using bulk detection. As a professional analytical chemist, you have only begun a lifetime of self-education.

引用

收藏

页码：316a / 324a

页数：9

相关论文

共 42 条

[11] Data registration and selective single-molecule analysis using multi-parameter fluorescence detection [J].

Eggeling, C ;

Berger, S ;

Brand, L ;

Fries, JR ;

Schaffer, J ;

Volkmer, A ;

Seidel, CAM .

JOURNAL OF BIOTECHNOLOGY, 2001, 86 (03) :163-180

[12] SORTING SINGLE MOLECULES - APPLICATION TO DIAGNOSTICS AND EVOLUTIONARY BIOTECHNOLOGY [J].

EIGEN, M ;

RIGLER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5740-5747

[13] Optimal algorithm for single-molecule identification with time-correlated single-photon counting [J].

Enderlein, J ;

Sauer, M .

JOURNAL OF PHYSICAL CHEMISTRY A, 2001, 105 (01) :48-53

[14] Molecular beacons - Novel fluorescent probes [J].

Fang, XH ;

Li, JWJ ;

Perlette, J ;

Tan, WH ;

Wang, KM .

ANALYTICAL CHEMISTRY, 2000, 72 (23) :747A-753A

[15] Counting single chromophore molecules for ultrasensitive analysis and separations on microchip devices [J].

Fister, JC ;

Jacobson, SC ;

Davis, LM ;

Ramsey, JM .

ANALYTICAL CHEMISTRY, 1998, 70 (03) :431-437

[16] IMAGING OF SINGLE FLUORESCENT MOLECULES AND INDIVIDUAL ATP TURNOVERS BY SINGLE MYOSIN MOLECULES IN AQUEOUS-SOLUTION [J].

FUNATSU, T ;

HARADA, Y ;

TOKUNAGA, M ;

SAITO, K ;

YANAGIDA, T .

NATURE, 1995, 374 (6522) :555-559

[17]

Goodwin P. M., 1995, Experimental Technique of Physics, V41, P279

[18] Application of single molecule detection to DNA sequencing [J].

Goodwin, PM ;

Cai, H ;

Jett, JH ;

IshaugRiley, SL ;

Machara, NP ;

Semin, DJ ;

VanOrden, A ;

Keller, RA .

NUCLEOSIDES & NUCLEOTIDES, 1997, 16 (5-6) :543-550

[19] Identification of single fluorescently labelled mononucleotide molecules in solution by spectrally resolved time-correlated single-photon counting [J].

Herten, DP ;

Tinnefeld, P ;

Sauer, M .

APPLIED PHYSICS B-LASERS AND OPTICS, 2000, 71 (05) :765-771

[20] OPTICAL MICROSCOPIC OBSERVATION OF SINGLE SMALL MOLECULES [J].

HIRSCHFELD, T .

APPLIED OPTICS, 1976, 15 (12) :2965-2966

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