Discovery of imidazole glycerol phosphate dehydratase inhibitors through 3-D database searching

被引：17

作者：

Schweitzer, BA ^{[1
]}

Loida, PJ ^{[1
]}

CaJacob, CA ^{[1
]}

Chott, RC ^{[1
]}

Collantes, EM ^{[1
]}

Hegde, SG ^{[1
]}

Mosier, PD ^{[1
]}

Profeta, S ^{[1
]}

机构：

[1] Monsanto Co, St Louis, MO 63167 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(02)00283-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Imidazole glycerol phosphate dehydratase (IGPD) has become an attractive target for herbicide discovery since it is present in plants and not in mammals. Currently no knowledge is available on the 3-D structure of the IGPD active site. Therefore, we used a pharmacophore model based on known inhibitors and 3-D database searches to identify new active compounds. In vitro testing of compounds from the database searches led to the identification of a class of pyrrole aldehydes as novel inhibitors of IGPD. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1743 / 1746

页数：4

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