The complex relationship of gene duplication and essentiality

被引：72

作者：

Makino, Takashi ^{[1
]}

Hokamp, Karsten ^{[1
]}

McLysaght, Aoife ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Smurfit Inst Genet, Dublin 2, Ireland

来源：

TRENDS IN GENETICS | 2009年 / 25卷 / 04期

基金：

爱尔兰科学基金会;

关键词：

WHOLE-GENOME DUPLICATION; EVOLUTION; VERTEBRATE; ROBUSTNESS; MUTATIONS; ORIGIN; FISHES; MOUSE; YEAST;

D O I：

10.1016/j.tig.2009.03.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In yeast and worm, duplicate genes overlap in function so that deleting one of a pair from the genome is less likely to be lethal than deleting a singleton gene. By contrast, previous analyses showed that mouse duplicate genes were as essential as singletons. We show that the relationship between gene duplication and essentiality is complex in multicellular organisms, with developmental genes and genes that were duplicated by whole genome duplication being more essential than other duplicated genes.

引用

页码：152 / 155

页数：4

共 31 条

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