New natural product biosynthetic chemistry discovered by genome mining

被引：111

作者：

Corre, Christophe ^{[1
]}

Challis, Gregory L. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

NATURAL PRODUCT REPORTS | 2009年 / 26卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

NONRIBOSOMAL PEPTIDE SYNTHETASE; STREPTOMYCES-COELICOLOR GENOME; III POLYKETIDE SYNTHASE; ASSEMBLY-LINE ENZYMOLOGY; CATALYZES CYCLODIMERIZATION; STIGMATELLA-AURANTIACA; OXIDOSQUALENE CYCLASE; BACTERIAL GENOMICS; BACILLUS-SUBTILIS; GENE-CLUSTER;

D O I：

10.1039/b713024b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analyses of plant and microbial genome sequences have revealed many genes and gene clusters encoding proteins similar to those known to be involved in the biosynthesis of structurally-complex natural products. Many of these genes and gene clusters do not direct the production of known metabolites of the organism in which they are found. Others represent novel gene clusters that direct the biosynthesis of known natural products. This article highlights several examples of new biosynthetic chemistry discovered in the course of investigating such gene clusters.

引用

页码：977 / 986

页数：10

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