Convenient oxidation of alkylated phenols and methoxytoluenes to antifungal 1,4-benzoquinones with hydrogen peroxide (H2O2)/methyltrioxorhenium (CH3ReO3) catalytic system in neutral ionic liquid

被引：44

作者：

Bernini, Roberta

Mincione, Enrico

Barontini, Maurizio

Fabrizi, Giancarlo

Pasqualetti, Marcella

Tempesta, Sabrina

机构：

[1] Univ Tuscia, Dipartimento Agrobiol & Agrochim, I-01100 Viterbo, Italy

[2] Consorzio Interuniv La Chim Ambiente, Unita Ric VT2, I-30175 Marghera, VE, Italy

[3] Univ Roma La Sapienza, Dipartimento Studi CHim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[4] Univ Tuscia, Dipartimento Ecol & Sviluppo Econ Sostenibile, I-01100 Viterbo, Italy

来源：

TETRAHEDRON | 2006年 / 62卷 / 33期

关键词：

hydrogen peroxide/methyltrioxorhenium; catalytic oxidations; 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4; 1,4-benzoquinones; antifungal activity;

D O I：

10.1016/j.tet.2006.05.069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylated phenol and methoxytoluene derivatives were catalytically and selectively oxidized to the corresponding 1,4-benzoquinones in good conversions and yields. Reactions were performed with hydrogen peroxide (H2O2)/methyltrioxorhenium (CH3ReO3) in 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4, aneutral ionic liquid. Compounds were tested in vitro for their antifungal activity against the growth of several widespread soil fungi. Some of them were proved to be potent inhibitors of Fusarium sp. than ketoconazole, a commercially available and expensive antifungal agent. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7733 / 7737

页数：5

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