Serum Concentrations of Rifampin, Isoniazid, and Intestinal Absorption, Permeability in Patients with Multidrug Resistant Tuberculosis

被引：22

作者：

Barroso, Elizabeth C. ^{[1
]}

Pinheiro, Valeria G. F. ^{[1
]}

Facanha, Monica C. ^{[1
]}

Carvalho, Maria R. D. ^{[1
]}

Moura, Maria E. ^{[1
]}

Campelo, Creusa L. ^{[1
]}

Peloquin, Charles A. ^{[3
,4
]}

Guerrant, Richard L. ^{[2
]}

Lima, Aldo A. M. ^{[1
]}

机构：

[1] Univ Fed Ceara, Sch Med, Dept Physiol & Pharmacol, INCT Inst Biomed Ctr Global Hlth, Fortaleza, Ceara, Brazil

[2] Univ Virginia, Ctr Global Hlth, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA

[3] Univ Florida, Coll Pharm, Gainesville, FL 32610 USA

[4] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2009年 / 81卷 / 02期

关键词：

PULMONARY TUBERCULOSIS; ANTITUBERCULOSIS DRUGS; ANTIMYCOBACTERIAL DRUGS; PLASMA-CONCENTRATIONS; INTERFERON-GAMMA; PHARMACOKINETICS; MALABSORPTION; DETERMINANTS; CHILDREN;

D O I：

10.4269/ajtmh.2009.81.322

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This study evaluates the serum concentrations of rifampin (RMP), isoniazid (INH), and intestinal barrier function in patients with multidrug-resistant tuberculosis (MDR-TB), drug susceptible tuberculosis (DS-TB). and health volunteers (HC; controls). Peak serum concentrations of RMP were significantly lower in MDR-TB and DS-TB as compared with HC (odds ratio [OR] = 3.125, confidence interval [CI] [1.037-9.418] and OR = 4.025, CI [1.207-13.418], respectively). The INH peak serum concentration was not significantly different between MDR-TB versus DS-TB or DS-TB versus HC. The percent of mannitol excretion was significantly lower in the MDR-TB group compared with DS-TB (13.18 versus 16.03. analysis of covariance [ANCOVA], P = 0.0369) and compared with HC (13.18 versus 16.61, ANCOVA, P = 0.0291) the other study groups. These data suggested a lower peak serum concentration of RMP for both MDR-TB and DS-TB as compared with the HC group. The data also showed a lower intestinal area of absorption in patients with tuberculosis and even worse in MDR-TB.

引用

页码：322 / 329

页数：8

共 39 条

[11]

*CEAR SECR EST SAU, 2007, SIT EP TUB CEAR INF

[12] Pharmacokinetics of antimycobacterial drugs in patients with tuberculosis, AIDS, and diarrhea [J].