Microwave-assisted Suzuki-Miyaura reactions with an insoluble pyridine-aldoxime Pd-catalyst

被引：60

作者：

Solodenko, W

Schön, U

Messinger, J

Glinschert, A

Kirschning, A

机构：

[1] Univ Hannover, Zentrum Organ Chem, D-30167 Hannover, Germany

[2] Solvay Pharmaceut Res Labs, D-30173 Hannover, Germany

来源：

SYNLETT | 2004年 / 10期

关键词：

Suzuki-Miyaura reactions; precatalyst; pyridine-aldoxime Pd-catalyst;

D O I：

10.1055/s-2004-829546

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of a solid Pd(II)-precatalyst and its use in microwave-assisted Suzuki-Miyaura reactions in water is described. The precatalyst is obtained by treatment of 4-pyridine-aldoxime with Na2PdCl4 and is insoluble in organic solvents as well as in water. Its robustness under microwave conditions and its insolubility allows simple reuse in 'teabags'.

引用

收藏

页码：1699 / 1702

页数：4

相关论文

共 31 条

[21]

2-L

[22] Microwave-assisted high-speed chemistry: a new technique in drug discovery [J].

Larhed, M ;

Hallberg, A .

DRUG DISCOVERY TODAY, 2001, 6 (08) :406-416

[23] Transition-metal-free Suzuki-type coupling reactions [J].

Leadbeater, NE ;

Marco, M .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (12) :1407-1409

[24] Increasing rates of reaction: Microwave-assisted organic synthesis for combinatorial chemistry [J].

Lew, A ;

Krutzik, PO ;

Hart, ME ;

Chamberlin, AR .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2002, 4 (02) :95-105

[25] Recoverable catalysts and reagents using recyclable polystyrene-based supports [J].

McNamara, CA ;

Dixon, MJ ;

Bradley, M .

CHEMICAL REVIEWS, 2002, 102 (10) :3275-3299

[26] Di-2-pyridylmethylamine-based palladium complexes as new catalysts for Heck, Suzuki, and Sonogashira reactions in organic and aqueous solvents [J].

Nájera, C ;

Gil-Moltó, J ;

Karlstrom, S ;

Falvello, LR .

ORGANIC LETTERS, 2003, 5 (09) :1451-1454

[27] AROMATIC METALATION REACTIONS BY PALLADIUM(II) AND PLATINUM(II) ON AROMATIC ALDOXIMES AND KETOXIMES [J].

ONOUE, H ;

MINAMI, K ;

NAKAGAWA, K .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1970, 43 (11) :3480-+

[28] A tentative rationalization of microwave effects in organic synthesis according to the reaction medium, and mechanistic considerations [J].

Perreux, L ;

Loupy, A .

TETRAHEDRON, 2001, 57 (45) :9199-9223

[29]

SCHON U, 2004, 11 ADV LIB DES ORG S

[30]

Solodenko W., 2003, POLYM MAT ORGANIC SY, P201

← 1 2 3 4 →