Brain Derived Neurotrophic Factor Val66Met Polymorphism, the Five Factor Model of Personality and Hippocampal Volume: Implications for Depressive Illness

被引:64
作者
Joffe, Russell T. [1 ]
Gatt, Justine M. [2 ,3 ]
Kemp, Andrew H. [2 ,3 ]
Grieve, Stuart [4 ,5 ]
Dobson-Stone, Carol [6 ,7 ,8 ]
Kuan, Stacey A. [2 ,3 ]
Schofield, Peter R. [6 ,7 ,8 ]
Gordon, Evian [2 ,3 ,4 ,5 ]
Williams, Leanne M. [2 ,3 ]
机构
[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Psychiat, Newark, NJ 07103 USA
[2] Univ Sydney, Westmead Hosp, Westmead Millennium Inst, Brain Dynam Ctr, Westmead, NSW 2145, Australia
[3] Univ Sydney, Western Clin Sch, Westmead, NSW 2145, Australia
[4] Brain Resource Co, Ultimo, NSW, Australia
[5] Brain Resource Int Database, Ultimo, NSW, Australia
[6] Garvan Inst Med Res, Sydney, NSW, Australia
[7] Univ New S Wales, Sydney, NSW, Australia
[8] Prince Wales Med Res Inst, Sydney, NSW, Australia
基金
澳大利亚研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
brain derived neurotrophic factor Val66Met polymorphism; BDNF; hippocampus; neuroticism; five factor model; depression; ANXIETY STRESS SCALES; FAMILY-BASED ASSOCIATION; LARGE NONCLINICAL SAMPLE; FACTOR BDNF GENE; MAJOR DEPRESSION; BIPOLAR DISORDER; MOOD DISORDERS; CLINICAL CHARACTERISTICS; PSYCHOMETRIC PROPERTIES; TAXOMETRIC ANALYSIS;
D O I
10.1002/hbm.20592
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Altered hippocampal volume, the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and neuroticism have each been implicated in the etiology of psychiatric disorders, especially depression. However, the relationship between these variables is not well understood. Here, we determined the effects of the BDNF Val66met polymorphism on the five-factor personality dimensions (assessed using the NEO-FFI), trait depression (assessed with the DASS-21) in a cross-sectional cohort of 467 healthy volunteers. A large matched subset of this cohort was also assessed for grey matter volume of the hippocampus and contiguous temporal cortical regions using magnetic resonance imaging. In Met carriers, elevations in neuroticism and trait depression and stress were associated with lower mean hippocampal volume, but there were no such associations in Val homozygotes. Trait depression, in particular, was found to moderate the effects of BDNF genotypes on hippocampal volume. Met carriers with high trait depression showed a reduction in grey matter volume of the mean hippocampus compared with Val homozygotes. These findings suggest that even in otherwise healthy subjects, trait depression may contribute to the susceptibility of Met carriers to hippocampal grey matter loss. Hum Brain Mapp 30:1246-1256, 2009. (C) 2008 Wiley-Liss, Inc.
引用
收藏
页码:1246 / 1256
页数:11
相关论文
共 63 条
[41]   Course of illness, hippocampal function, and hippocampal volume in major depression [J].
MacQueen, GM ;
Campbell, S ;
McEwen, BS ;
MacDonald, K ;
Amano, S ;
Joffe, RT ;
Nahmias, C ;
Young, LT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) :1387-1392
[42]   Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus [J].
Malberg, JE ;
Eisch, AJ ;
Nestler, EJ ;
Duman, RS .
JOURNAL OF NEUROSCIENCE, 2000, 20 (24) :9104-9110
[43]   Glucocorticoids, depression, and mood disorders: structural remodeling in the brain [J].
McEwen, BS .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2005, 54 (05) :20-23
[44]   Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder [J].
Nakata, K ;
Ujike, H ;
Sakai, A ;
Uchida, N ;
Nomura, A ;
Imamura, T ;
Katsu, T ;
Tanaka, Y ;
Hamamura, T ;
Kuroda, S .
NEUROSCIENCE LETTERS, 2003, 337 (01) :17-20
[45]   The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology [J].
Nemoto, K ;
Ohnishi, T ;
Mori, T ;
Moriguchi, Y ;
Hashimoto, R ;
Asada, T ;
Kunugi, H .
NEUROSCIENCE LETTERS, 2006, 397 (1-2) :25-29
[46]   The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: Evidence from a family-based association study [J].
Neves-Pereira, M ;
Mundo, E ;
Muglia, P ;
King, N ;
Macciardi, F ;
Kennedy, JL .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (03) :651-655
[47]   Atypical depression: A reappraisal [J].
Parker, G ;
Roy, K ;
Mitchell, P ;
Wilhelm, K ;
Malhi, G ;
Hadzi-Pavlovic, D .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (09) :1470-1479
[48]   The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology [J].
Pezawas, L ;
Verchinski, BA ;
Mattay, VS ;
Callicott, JH ;
Kolachana, BS ;
Straub, RE ;
Egan, MF ;
Meyer-Lindenberg, A ;
Weinberger, DR .
JOURNAL OF NEUROSCIENCE, 2004, 24 (45) :10099-10102
[49]   The possibility of neurotoxicity in the hippocampus in major depression: A primer on neuron death [J].
Sapolsky, RM .
BIOLOGICAL PSYCHIATRY, 2000, 48 (08) :755-765
[50]   Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders [J].
Sapolsky, RM .
ARCHIVES OF GENERAL PSYCHIATRY, 2000, 57 (10) :925-935