A cell-based screening to detect inhibitors of BRAF signaling pathway

被引:3
作者
Asami, Yukihiro [1 ,2 ]
Mori, Mihoko [1 ,2 ]
Koshino, Hiroyuki [3 ]
Sekiyama, Yasuyo [1 ,2 ]
Teruya, Takayuki [1 ,2 ]
Simizu, Siro [1 ,2 ]
Usui, Takeo [1 ,2 ]
Osada, Hiroyuki [1 ,2 ]
机构
[1] RIKEN, Antibiot Lab, Wako, Saitama 3510198, Japan
[2] RIKEN, Dept Biol Chem, Wako, Saitama 3510198, Japan
[3] RIKEN, Adv Sci Inst, Adv Technol Support Div, Mol Characterizat Team, Wako, Saitama 3510198, Japan
关键词
BRAF; cell-based assay; malformins; protein phosphatase; signal transduction; MALFORMIN; KINASE; PHOSPHORYLATION; METABOLITE;
D O I
10.1038/ja.2008.17
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
[No abstract available]
引用
收藏
页码:105 / 107
页数:3
相关论文
共 19 条
[1]   MALFORMIN-C, A NEW METABOLITE OF ASPERGILLUS-NIGER [J].
ANDEREGG, RJ ;
BIEMANN, K ;
BUCHI, G ;
CUSHMAN, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (11) :3365-3370
[2]   RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus [J].
Asami, Yukihiro ;
Kakeya, Hideaki ;
Okada, Gen ;
Toi, Masakazu ;
Osada, Hiroyuki .
JOURNAL OF ANTIBIOTICS, 2006, 59 (11) :724-728
[3]  
BANNON PG, 1994, THROMB HAEMOSTASIS, V72, P482
[4]   Functional analysis of the regulatory requirements of B-Raf and the B-RafV600E oncoprotein [J].
Brummer, T. ;
Martin, P. ;
Herzog, S. ;
Misawa, Y. ;
Daly, R. J. ;
Reth, M. .
ONCOGENE, 2006, 25 (47) :6262-6276
[5]   Mutations of the BRAF gene in human cancer [J].
Davies, H ;
Bignell, GR ;
Cox, C ;
Stephens, P ;
Edkins, S ;
Clegg, S ;
Teague, J ;
Woffendin, H ;
Garnett, MJ ;
Bottomley, W ;
Davis, N ;
Dicks, N ;
Ewing, R ;
Floyd, Y ;
Gray, K ;
Hall, S ;
Hawes, R ;
Hughes, J ;
Kosmidou, V ;
Menzies, A ;
Mould, C ;
Parker, A ;
Stevens, C ;
Watt, S ;
Hooper, S ;
Wilson, R ;
Jayatilake, H ;
Gusterson, BA ;
Cooper, C ;
Shipley, J ;
Hargrave, D ;
Pritchard-Jones, K ;
Maitland, N ;
Chenevix-Trench, G ;
Riggins, GJ ;
Bigner, DD ;
Palmieri, G ;
Cossu, A ;
Flanagan, A ;
Nicholson, A ;
Ho, JWC ;
Leung, SY ;
Yuen, ST ;
Weber, BL ;
Siegler, HF ;
Darrow, TL ;
Paterson, H ;
Marais, R ;
Marshall, CJ ;
Wooster, R .
NATURE, 2002, 417 (6892) :949-954
[6]   V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors [J].
Grbovic, OM ;
Basso, AD ;
Sawai, A ;
Ye, Q ;
Friedlander, P ;
Solit, D ;
Rosen, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (01) :57-62
[7]   Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells [J].
Hagimori, Keiichi ;
Fukuda, Takashi ;
Hasegawa, Yoko ;
Omura, Satoshi ;
Tomoda, Hiroshi .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (08) :1379-1383
[8]   MALFORMIN-A1 INHIBITS THE BINDING OF INTERLEUKIN-1-BETA (IL1-BETA) AND SUPPRESSES THE EXPRESSION OF TISSUE FACTOR IN HUMAN ENDOTHELIAL-CELLS AND MONOCYTES [J].
HERBERT, JM ;
SAVI, P ;
LALE, A ;
LAPLACE, MC ;
BAUDRY, N ;
PEREILLO, JM ;
EMONDSALT, X .
BIOCHEMICAL PHARMACOLOGY, 1994, 48 (06) :1211-1217
[9]   The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments [J].
Janosch, P ;
Kieser, A ;
Eulitz, M ;
Lovric, J ;
Sauer, G ;
Reichert, M ;
Gounari, F ;
Büscher, D ;
Baccarini, M ;
Mischak, H ;
Kolch, W .
FASEB JOURNAL, 2000, 14 (13) :2008-2021
[10]   STRUCTURE OF MALFORMIN-A, A PHYTOTOXIC METABOLITE PRODUCED BY ASPERGILLUS-NIGER [J].
KIM, KW ;
SUGAWARA, F ;
YOSHIDA, S ;
MUROFUSHI, N ;
TAKAHASHI, N ;
CURTIS, RW .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1993, 57 (02) :240-243