QSAR studies on biological activity of piritrexim analogues against pc DHFR

被引：15

作者：

Agrawal, VK

Sohgaura, R

Khadikar, PV

机构：

[1] Luxmi Fumigat & Pest Control Ltd, Div Res, Indore 452007, India

[2] APS Univ, Comp & QSAR Labs, Rewa 486003, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0968-0896(02)00159-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantitative structure-activity relationship (QSAR) Studies for 2,6-substituted 2,4-diaminopyrido[3,2-d] pyrimidine analogues of piritrexim (PTX) as inhibitors of dihydrofolate reductase (DHFR) are now made using topological indices, The results have shown that best models are obtained by multiparametric analysis. The predictive potential of the model is discussed on the basis of a cross-validation method. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2919 / 2926

页数：8

共 27 条

[1] QSAR study on inhibition of brain 3-hydroxy-anthranilic acid dioxygenase (3-HAO): A molecular connectivity approach [J].