Properties of a versatile nanoparticle platform contrast agent to image and characterize atherosclerotic plaques by magnetic resonance imaging

被引：126

作者：

Frias, Juan C.

Ma, Yanqing

Williams, Kevin Jon

Fayad, Zahi A. ^{[1
]}

Fisher, Edward A.

机构：

[1] CUNY Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

[2] CUNY Mt Sinai Sch Med, Marie Josee & Henry R Kravis Cardiovasc Hlth Ctr, New York, NY 10029 USA

[3] NYU, Sch Med, Leon H Charney Div Cardiol, Dept Med, New York, NY 10016 USA

[4] Thomas Jefferson Univ, Philadelphia, PA 19107 USA

来源：

NANO LETTERS | 2006年 / 6卷 / 10期

关键词：

D O I：

10.1021/nl061498r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The need for more specific and selective contrast agents for magnetic resonance imaging motivated us to prepare a new nanoparticle agent based on high-density lipoproteins (HDL). This second generation contrast agent can be prepared in three different ways. The HDL nanoparticles (rHDL) were fully characterized by FPLC and gel electrophoresis. The flexibility of the platform also allows us to incorporate optical probes into rHDL for localization ex vivo by confocal fluorescence microscopy. The contrast-agent-containing nanoparticles were injected into mice that develop atherosclerotic lesions. Magnetic resonance imaging of the animals showed clear enhancement of the atherosclerotic plaques.

引用

收藏

页码：2220 / 2224

页数：5

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