Discovery of pyrroloimidazoles as agents stimulating neurite outgrowth

被引：14

作者：

Beck, Barbara

Leppert, Christian A.

Mueller, Bernhard K.

Doemling, Alexander

机构：

[1] Morphochem AG, D-81379 Munich, Germany

[2] Migragen AG, D-72076 Tubingen, Germany

来源：

QSAR & COMBINATORIAL SCIENCE | 2006年 / 25卷 / 5-6期

关键词：

multicomponent reaction; isocyanide; phenotype assay; neurite outgrowth;

D O I：

10.1002/qsar.200540300

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A diverse library of substituted pyrroloimidazoles was assembled by a multicomponent reaction (MCR) of tosylmethyl isocyanides (TOSMIC), indole carbaldehydes and primary amines in a van Leusen reaction. A library of this scaffold was screened in a phenotypic assay for neurite outgrowth. Several members of this library where found to promote neurite outgrowth. The combinatorial synthesis of the library is presented. Such small molecules will serve as useful chemical probes to study neurite growth and may ultimately lead to a therapeutic application for axon regeneration of lesions of the human spinal cord and brain.

引用

页码：527 / 535

页数：9

共 21 条

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