Distribution of NPM1-ALK and X-ALK fusion transcripts in paediatric anaplastic large cell lymphoma: a molecular-histological correlation

被引：48

作者：

Damm-Welk, Christine ^{[1
]}

Klapper, Wolfram ^{[2
,3
]}

Oschlies, Ilske ^{[2
,3
]}

Gesk, Stefan ^{[4
,5
]}

Roettgers, Silja ^{[1
]}

Bradtke, Jutta ^{[1
]}

Siebert, Reiner ^{[4
,5
]}

Reiter, Alfred ^{[1
]}

Woessmann, Willi ^{[1
]}

机构：

[1] Univ Giessen, Dept Paediat Haematol & Oncol, D-35392 Giessen, Germany

[2] Univ Hosp Schleswig Holstein, Dept Pathol, Haematopathol Sect, Kiel, Germany

[3] Univ Hosp Schleswig Holstein, Lymph Node Registry, Kiel, Germany

[4] Univ Hosp Schleswig Holstein, Inst Human Genet, Kiel, Germany

[5] Univ Kiel, Kiel, Germany

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2009年 / 146卷 / 03期

关键词：

anaplastic large cell lymphoma; anaplastic lymphoma kinase; NPM-ALK; reverse transcription polymerase chain reaction; paediatric; NPM-ALK; TUMOR;

D O I：

10.1111/j.1365-2141.2009.07754.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Anaplastic large cell lymphomas (ALCL) in children express anaplastic lymphoma kinase (ALK) fusion genes, most commonly NPM1-ALK. The distribution of X-ALK among 66 childhood ALCLs was analysed. One ALCL was ALK-negative. Reverse transcription polymerase chain reaction detected NPM1-ALK in 58 tumours, all showing nuclear and cytoplasmic ALK staining. The remaining seven ALCL stained for ALK in the cytoplasm only: two expressed TPM3-ALK, one ATIC-ALK, one MYH9-ALK; three no TPM3-, TFG-, ATIC-, CLTC- or MYH9-ALK. Almost 90% of paediatric ALK-positive ALCLs express NPM1-ALK. There was complete concordance between ALK staining pattern and the presence of a typical/variant ALK fusion partner.

引用

页码：306 / 309

页数：4

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