An efficient one-pot synthesis of 3,4-dihydropyrirnidin-2-ones catalyzed by methanesulfonic acid

被引：34

作者：

Jin, TS ^{[1
]}

Wang, HX ^{[1
]}

Xing, CY ^{[1
]}

Li, XL ^{[1
]}

Li, TS ^{[1
]}

机构：

[1] Hebei Univ, Dept Chem, Coll Chem & Environm Sci, Baoding 071002, Hebei Province, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 16期

基金：

中国国家自然科学基金;

关键词：

dihydropyrimidin-2(1H)-ones; methanesulfonic acid; synthesis;

D O I：

10.1081/SCC-200026660

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aidehydes, beta-ketoesters, and urea in ethanol using methanesulfonic acid (CH3SO3H) as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time.

引用

页码：3009 / 3016

页数：8

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