Evaluation of hypothalamic-pituitary-adrenal axis in premature infants treated with dexamethasone

被引:19
作者
Alkalay, AL
Klein, AH
Nagel, RA
Pomerance, JJ
机构
[1] Divisions Neonatologv Endocrinol., Ahmanson Pediatric Center, Univ. of California at Los Angeles, Los Angeles, CA
[2] Cedars-Sinai Medical Center, Los Angeles, CA 90048
关键词
dexamethasone; hypothalamic-pituitary-adrenal-axis;
D O I
10.1055/s-2007-994430
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Results of a national survey of the current use of steroids in newborns in 1993 showed that 95% of the neonatologists in the United Stales have used dexamethasone for neonates at risk for chronic lung disease. Dexamethasone therapy for a period of a week or longer is associated with suppression of the hypothalamic-pituitary-adrenal axis (HPAA) in a substantial number of premature infants. A review of our current understanding of the biochemical tests evaluating HPAA function in premature infants and suggested guidelines for HPAA evaluation and management following dexamethasone therapy are presented.
引用
收藏
页码:473 / 477
页数:5
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