The Structural and Functional Diversity of Metabolite-Binding Riboswitches

被引：430

作者：

Roth, Adam ^{[1
]}

Breaker, Ronald R. ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[3] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2009年 / 78卷

关键词：

aptamer; binding pocket; expression platform; ribozyme; GLYCINE-DEPENDENT RIBOSWITCH; CONTROLS GENE-EXPRESSION; MESSENGER-RNA STRUCTURE; S-MK BOX; LIGAND-BINDING; CRYSTAL-STRUCTURE; COMPARATIVE GENOMICS; THI-BOX; TRANSCRIPTION TERMINATION; MOLECULAR-RECOGNITION;

D O I：

10.1146/annurev.biochem.78.070507.135656

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cellular concentrations of certain metabolites are assiduously monitored to achieve appropriate levels of gene expression. Although proteins have long been known to act as sensors in this capacity, metabolite-binding RNAs, or riboswitches, also play an important role. More than 20 distinct classes of riboswitches have been identified to date, and insights to the molecular recognition strategies of a significant subset of these have been provided by detailed structural studies. This diverse set of metabolite-sensing RNAs is found to exploit a variety of distinct mechanisms to regulate genes that are fundamental to metabolism.

引用

页码：305 / 334

页数：30

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