Convenient synthesis of Cbz-protected β-amino ketones by a copper-catalysed conjugate addition reaction

被引：105

作者：

Wabnitz, TC ^{[1
]}

Spencer, JB ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 21期

关键词：

benzyl carbamate; conjugate addition; nitrogen nucleophiles; copper; beta-amino ketones;

D O I：

10.1016/S0040-4039(02)00654-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of Cbz-protected beta-amino ketones is reported. Benzyl carbamates and alpha,beta-unsaturated ketones furnish the conjugate addition products in the presence of a Cut(II) catalyst Under mild conditions. Other weakly basic nitrogen nucleophiles can also be Used in this reaction. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3891 / 3894

页数：4

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2-E

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