Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice

被引:44
作者
Sieve, AN [1 ]
Steelman, AJ [1 ]
Young, CR [1 ]
Storts, R [1 ]
Welsh, TH [1 ]
Welsh, CJR [1 ]
Meagher, MW [1 ]
机构
[1] Texas A&M Univ, Coll Liberal Arts, Dept Psychol, Behav & Cellular Neurosci Program, College Stn, TX 77843 USA
关键词
Theiler's murine encephalomyelitis virus (TMEV); restraint stress; demyelination; multiple sclerosis; myelin-reactive autoantibodies;
D O I
10.1016/j.jneuroim.2004.06.006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Chronic restraint stress, administered during early infection with Theiler's virus, was found to exacerbate the acute central nervous system (CNS) viral infection and the subsequent demyelinating phase of disease (an animal model of Multiple Sclerosis (MS)) in SJL male and female mice. During early infection, stressed mice displayed decreased body weights and spontaneous activity; while increased behavioral signs of illness and plasma corticosterone (CORT) levels. During the subsequent chronic demyelinating phase of disease, previously stressed mice had greater behavioral signs of the chronic phase, worsened rotarod performance, and increased inflammatory lesions of the spinal cord. In addition, mice developed autoantibodies to myelin basic protein (MBP), proteolipid protein peptide (PLP139-151), and myelin oligodendrocyte glycoprotein peptide (MOG33-55). (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:103 / 118
页数:16
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