Iodine-assisted matrix-assisted laser desorption/ionisation

被引：7

作者：

Bashir, S

Burkitt, WI

Derrick, PJ ^{[1
]}

Giannakopulos, AE

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Warwick, Inst Mass Spectrometry, Coventry CV4 7AL, W Midlands, England

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2002年 / 219卷 / 03期

关键词：

proteomics; MALDI; matrix;

D O I：

10.1016/S1387-3806(02)00749-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

Addition of iodine to the matrix has been found to lead to lower thresholds for ion formation in matrix-assisted laser desorption/ionisation (MALDI) of peptides and other compounds. Intensities of ions from the matrix have been suppressed through the addition of iodine to the matrix; intensities of ions corresponding to addition of sodium or potassium to the analyte have been diminished. These effects have been observed with a number of matrices, including 2,5-dihydroxybenzoic acid, dithranol and alpha-cyano-4-hydroxy-cinnamic acid.

引用

页码：697 / 701

页数：5

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