Brain-Derived Neurotrophic Factor Interacts with Adult-Born Immature Cells in the Dentate Gyrus During Consolidation of Overlapping Memories

被引：71

作者：

Bekinschtein, Pedro ^{[1
,2
,3
]}

Kent, Brianne A. ^{[1
,2
,3
]}

Oomen, Charlotte A. ^{[1
,2
,3
]}

Clemenson, Gregory D. ^{[4
]}

Gage, Fred H. ^{[4
]}

Saksida, Lisa M. ^{[1
,2
,3
]}

Bussey, Timothy J. ^{[1
,2
,3
]}

机构：

[1] Univ Cambridge, Dept Psychol, Cambridge, England

[2] Univ Cambridge, MRC, Cambridge, England

[3] Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Translat & Cognit Neurosci Lab, Cambridge, England

[4] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA

来源：

HIPPOCAMPUS | 2014年 / 24卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

memory consolidation; dentate gyrus; BDNF; neurogenesis; ENHANCED SYNAPTIC PLASTICITY; MEDIAL PREFRONTAL CORTEX; PATTERN SEPARATION; GRANULE CELLS; HIPPOCAMPAL NEUROGENESIS; OBJECT RECOGNITION; SPATIAL MEMORY; BDNF; RECEPTORS; LOCATION;

D O I：

10.1002/hipo.22304

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Successful memory involves not only remembering information over time but also keeping memories distinct and less confusable. The computational process for making representations of similar input patterns more distinct from each other has been referred to as "pattern separation." Although adult-born immature neurons have been implicated in this memory feature, the precise role of these neurons and associated molecules in the processing of overlapping memories is unknown. Recently, we found that brain-derived neurotrophic factor (BDNF) in the dentate gyrus is required for the encoding/consolidation of overlapping memories. In this study, we provide evidence that consolidation of these "pattern-separated" memories requires the action of BDNF on immature neurons specifically. (C) 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.

引用

页码：905 / 911

页数：7

共 32 条

[1]

Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation [J].