SNAREs - engines for membrane fusion

被引：1983

作者：

Jahn, Reinhard

Scheller, Richard H.

机构：

[1] Max Planck Inst Biophys Chem, Dept Neurobiol, D-37077 Gottingen, Germany

[2] Genentech Inc, San Francisco, CA 94080 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as key components of protein complexes that drive membrane fusion. Despite considerable sequence divergence among SNARE proteins, their mechanism seems to be conserved and is adaptable for fusion reactions as diverse as those involved in cell growth, membrane repair, cytokinesis and synaptic transmission. A fascinating picture of these robust nanomachines is emerging.

引用

收藏

页码：631 / 643

页数：13

相关论文

共 152 条

[11]

BLASI J, 1993, EMBO J, V12, P4821, DOI 10.1002/j.1460-2075.1993.tb06171.x

[12] A genomic perspective on membrane compartment organization [J].

Bock, JB ;

Matern, HT ;

Peden, AA ;

Scheller, RH .

NATURE, 2001, 409 (6822) :839-841

[13] The mechanisms of vesicle budding and fusion [J].

Bonifacino, JS ;

Glick, BS .

CELL, 2004, 116 (02) :153-166

[14] v-SNAREs control exocytosis of vesicles from priming to fusion [J].

Borisovska, M ;

Zhao, Y ;

Tsytsyura, Y ;

Glyvuk, N ;

Takamori, S ;

Matti, U ;

Rettig, J ;

Südhof, T ;

Bruns, D .

EMBO JOURNAL, 2005, 24 (12) :2114-2126

[15] Single molecule observation of liposome-bilayer fusion thermally induced by soluble N-ethyl maleimide sensitive-factor attachment protein receptors (SNAREs) [J].

Bowen, ME ;

Weninger, K ;

Brunger, AT ;

Chu, S .

BIOPHYSICAL JOURNAL, 2004, 87 (05) :3569-3584

[16] Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity [J].

Brandhorst, D ;

Zwilling, D ;

Rizzoli, SO ;

Lippert, U ;

Lang, T ;

Jahn, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2701-2706

[17] Structure and function of SNARE and SNARE-interacting proteins [J].

Brunger, AT .

QUARTERLY REVIEWS OF BIOPHYSICS, 2005, 38 (01) :1-47

[18] Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation [J].

Bryant, NJ ;

James, DE .

EMBO JOURNAL, 2001, 20 (13) :3380-3388

[19] A SNARE required for retrograde transport to the endoplasmic reticulum [J].

Burri, L ;

Varlamov, O ;

Doege, CA ;

Hofmann, K ;

Beilharz, T ;

Rothman, JE ;

Söllner, TH ;

Lithgow, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (17) :9873-9877

[20] PROTEIN-PROTEIN INTERACTIONS CONTRIBUTING TO THE SPECIFICITY OF INTRACELLULAR VESICULAR TRAFFICKING [J].

CALAKOS, N ;

BENNETT, MK ;

PETERSON, KE ;

SCHELLER, RH .

SCIENCE, 1994, 263 (5150) :1146-1149

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