SNAREs - engines for membrane fusion

被引：1983

作者：

Jahn, Reinhard

Scheller, Richard H.

机构：

[1] Max Planck Inst Biophys Chem, Dept Neurobiol, D-37077 Gottingen, Germany

[2] Genentech Inc, San Francisco, CA 94080 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as key components of protein complexes that drive membrane fusion. Despite considerable sequence divergence among SNARE proteins, their mechanism seems to be conserved and is adaptable for fusion reactions as diverse as those involved in cell growth, membrane repair, cytokinesis and synaptic transmission. A fascinating picture of these robust nanomachines is emerging.

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收藏

页码：631 / 643

页数：13

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