ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

被引：708

作者：

Sun, Wenxiang ^{[1
]}

Li, Yang ^{[1
]}

Chen, Lu ^{[1
]}

Chen, Huihui ^{[1
]}

You, Fuping ^{[1
]}

Zhou, Xiang ^{[1
]}

Zhou, Yi ^{[1
]}

Zhai, Zhonghe ^{[1
]}

Chen, Danying ^{[1
]}

Jiang, Zhengfan ^{[1
]}

机构：

[1] Peking Univ, Sch Life Sci, Educ Minist, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 21期

基金：

中国国家自然科学基金;

关键词：

innate immunity; type I IFN; functional cDNA library screening; cytosolic RNA and dsDNA; ER retention signal; NF-KAPPA-B; DOUBLE-STRANDED-RNA; RIG-I; ADAPTER PROTEIN; ANTIVIRAL RESPONSE; MEMBRANE-PROTEINS; VIRUS; RECOGNITION; RECEPTORS; DNA;

D O I：

10.1073/pnas.0900850106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non-self-cytosolic RNA and dsDNA. ERIS (also known as STING or MITA) resided exclusively on ER membrane. The ER retention/retrieval sequence RIR was found to be critical to retain the protein on ER membrane and to maintain its integrity. ERIS was dimerized on innate immune challenges. Coumermycin-induced ERIS dimerization led to strong and fast IFN induction, suggesting that dimerization of ERIS was critical for self-activation and subsequent downstream signaling.

引用

页码：8653 / 8658

页数：6

共 35 条

[31] The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses [J].

Yoneyama, M ;

Kikuchi, M ;

Natsukawa, T ;

Shinobu, N ;

Imaizumi, T ;

Miyagishi, M ;

Taira, K ;

Akira, S ;

Fujita, T .

NATURE IMMUNOLOGY, 2004, 5 (07) :730-737

[32] Structural mechanism of RNA recognition by the RIG-l-like receptors [J].

Yoneyama, Mitsutoshi ;

Fujita, Takashi .

IMMUNITY, 2008, 29 (02) :178-181

[33] A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane KATP channels [J].

Zerangue, N ;

Schwappach, B ;

Jan, YN ;

Jan, LY .

NEURON, 1999, 22 (03) :537-548

[34] The voltage-gated Na+ channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit [J].

Zhang, Zhen-Ning ;

Li, Qian ;

Liu, Chao ;

Wang, Hai-Bo ;

Wang, Qiong ;

Bao, Lan .

JOURNAL OF CELL SCIENCE, 2008, 121 (19) :3243-3252

[35] The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation [J].

Zhong, Bo ;

Yang, Yan ;

Li, Shu ;

Wang, Yan-Yi ;

Li, Ying ;

Diao, Feici ;

Lei, Caoqi ;

He, Xiao ;

Zhang, Lu ;

Tien, Po ;

Shu, Hong-Bing .

IMMUNITY, 2008, 29 (04) :538-550

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