The extent of myocardial damage assessed by contrast-enhanced MRI is a major determinant of N-BNP concentration after myocardial infarction

被引：32

作者：

Cochet, A

Zeller, M

Cottin, Y

Robert-Valla, C

Lalande, A

L'Huilllier, I

Comte, A

Walker, PM

Desgres, J

Wolf, JE

Brunotte, F

机构：

[1] CHU Bocage, Serv Cardiol, F-21034 Dijon, France

[2] CHU Hop Enfants, Unite IRM, F-21034 Dijon, France

[3] CHU Hop Enfants, Biochim Lab, F-21034 Dijon, France

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2004年 / 6卷 / 05期

关键词：

brain natriuretic peptide; myocardial infarction; magnetic resonance imaging (MRI); delayed CE-MRI;

D O I：

10.1016/j.ejheart.2003.11.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: To evaluate the relationship between N-terminal Pro-Brain Natriuretic Peptide (N-BNP) level and contrast-enhanced MRI in patients after acute myocardial infarction (MI). Methods: Eighty-two patients were studied. Venous blood samples were obtained 3 days after MI and MRI was performed from 2 to 7 days after MI, with determination of left ventricular function and acquisition of perfusion data after injection of gadolinium-DTPA. First-pass images (FPI) and Delayed contrast-enhanced (CE) images were analyzed using a 17-segment model, and the extent of transmurality was determined by a visual score. Results: Univariate analysis showed that age (P < 0.001), sex (P < 0.02), Left Ventricular Ejection Fraction (LVEF) <45%(P < 0.002), creatinine (P < 0.05) and delayed CE-MR images (P < 0.006)were predictors of a supramedian N-BNP level. FPI was not a predictor in this univariate analysis (P < 0.078). In a multivariate model, only age, LVEF <45% and delayed CE-MRI were associated with an increased N-BNP level. Conclusion: After MI, high N-BNP levels are dependent on the LVEF but also on the myocardial infarct size derived from the delayed CE-MR images. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：555 / 560

页数：6

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