Hydroxymethylation of organic halides. Evaluation of a catalytic system involving a fluorous tin hydride reagent for radical carbonylation

被引：60

作者：

Ryu, I ^{[1
]}

Niguma, T ^{[1
]}

Minakata, S ^{[1
]}

Komatsu, M ^{[1
]}

Hadida, S ^{[1
]}

Curran, DP ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT CHEM,PITTSBURGH,PA 15260

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(97)10076-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydroxymethylation of organic halides 2 using a catalytic amount of fluorous tin hydride 1, CO, and NaBH3CN as a reducing agent, proceeded smoothly to give one-carbon homologated alcohols 5 in good yields. Three phase workup (water-dichloromethane-perfluorohexane) was conveniently performed for the separation of 1 and 5. (C) 1997 Elsevier Science Ltd.

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页码：7883 / 7886

页数：4

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