Light-Regulated Activation of Cellular Signaling by Gold Nanoparticles That Capture and Release Amines

被引：47

作者：

Nakanishi, Jun ^{[1
,2
]}

Nakayama, Hidekazu ^{[1
,2
]}

Shimizu, Takahiro ^{[3
]}

Ishida, Haruhisa ^{[3
]}

Kikuchi, Yukiko ^{[1
]}

Yamaguchi, Kazuo ^{[3
]}

Horiike, Yasuhiro ^{[1
]}

机构：

[1] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton, World Premier Int Res Ctr Initiat, Tsukuba, Ibaraki 3050044, Japan

[2] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[3] Kanagawa Univ, Fac Sci, Dept Mat Sci, Kanagawa 2591293, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 11期

关键词：

DELIVERY; MOLECULES; CELLS; DNA;

D O I：

10.1021/ja809236a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.

引用

页码：3822 / +

页数：3

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