Novel synthetic methodologies for fluorination and perfluoroalkylation

被引：27

作者：

Adams, DJ ^{[1
]}

Clark, JH ^{[1
]}

Heath, PA ^{[1
]}

Hansen, LB ^{[1
]}

Sanders, VC ^{[1
]}

Tavener, SJ ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2000年 / 101卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

fluorination; perfluoroalkylation; fluorodenitration; trifluoromethyltrimethylsilane;

D O I：

10.1016/S0022-1139(99)00157-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Nucleophilic routes to selectively fluorinated aromatic compounds starting from cheap and readily available nitroaromatics are reviewed. Me3SiCF3, in conjunction with a fluoride, can be used as either a fluorinating or trifluoromethylating agent, and is capable of both the trifluoromethyldenitration and trifluoromethyldecyanation of an aromatic molecule. Nucleophilic trifluoromethylthiolation can be achieved using thiophosgene and a fluoride. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：187 / 191

页数：5

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