Studies on the total synthesis of the macrolide antitumor agent rhizoxin .2. Synthesis of the C14-C26 segment.

被引：23

作者：

White, JD

Holoboski, MA

Green, NJ

机构：

[1] Department of Chemistry, Oregon State University, Corvallis

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 42期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)01781-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of the C14-C26 segment of rhizoxin as described in which the three stereogenic centers are derived from a gamma-lactone; stannylcupration-methylation of a terminal alkyne is used to generate an (E)-iodoalkene for Stille coupling with a dienylstannane that produces the conjugated (E,E,E)-triene unit of rhizoxin. (C) 1997 Elsevier Science Ltd.

引用

页码：7333 / 7336

页数：4

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