A novel PEG-based solid support enables the synthesis of >50 amino-acid peptide thioesters and the total synthesis of a functional SUMO-1 peptide conjugate

被引：31

作者：

Boll, Emmanuelle ^{[1
]}

Drobecq, Herve ^{[1
]}

Ollivier, Nathalie ^{[1
]}

Raibaut, Laurent ^{[1
]}

Desmet, Remi ^{[1
]}

Vicogne, Jerome ^{[1
]}

Melnyk, Oleg ^{[1
]}

机构：

[1] Univ Lille Nord France, Inst Pasteur Lille, UMR CNRS 8161, F-59021 Lille, France

来源：

CHEMICAL SCIENCE | 2014年 / 5卷 / 05期

关键词：

NATIVE CHEMICAL LIGATION; INTRAMOLECULAR N; S-ACYL SHIFT; EXPRESSED PROTEIN LIGATION; BIS(2-SULFANYLETHYL)AMIDO PEPTIDES; STAUDINGER LIGATION; UBIQUITIN CHAINS; PHASE SYNTHESIS; CHEMISTRY; UBIQUITYLATION; DIUBIQUITIN;

D O I：

10.1039/c3sc53509f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A bis(2-sulfanylethyl) amino PEG-based resin enabled the synthesis of large (similar to 50 Aa) SEA or thioester peptides using Fmoc-SPPS. These peptide segments permitted the first total synthesis of a 97 amino-acid long SUMO-1-SEA peptide thioester surrogate and of a functional and reversible SUMO-1 peptide conjugate.

引用

页码：2017 / 2022

页数：6

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A novel PEG-based solid support enables the synthesis of &gt;50 amino-acid peptide thioesters and the total synthesis of a functional SUMO-1 peptide conjugate

A novel PEG-based solid support enables the synthesis of >50 amino-acid peptide thioesters and the total synthesis of a functional SUMO-1 peptide conjugate