Relaxin as a Protective Substance in the Preserving Solution for Liver Transplantation Spectrophotometric in Vivo Imaging of Local Oxygen Supply in an Isolated Perfused Rat Liver Model

被引：14

作者：

Boehnert, Markus U. ^{[1
]}

Armbruster, Franz Paul ^{[2
]}

Hilbig, Heidegard ^{[3
]}

机构：

[1] Univ Bern, Dept Visceral & Transplantat Surg, Inselspital, CH-3010 Bern, Switzerland

[2] ImmundiagnostAG, D-64625 Bensheim, Germany

[3] Univ Leipzig, Dept Anat, D-04103 Leipzig, Germany

来源：

RELAXIN AND RELATED PEPTIDES: FIFTH INTERNATIONAL CONFERENCE | 2009年 / 1160卷

关键词：

relaxin; ischemia reperfusion injury; liver; transplantation; imaging;

D O I：

10.1111/j.1749-6632.2008.03804.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ischemia reperfusion injury (IRI) is a problem in organ transplantation. Relaxin is known to have a protective effect against liver injury caused by IRI. Using a model of isolated perfused rat liver, the local oxygen supply in liver tissue was investigated by spectrophotometric in vivo imaging and compared to the protective effect of relaxin shown by immunohistochemical measurement of myeloperoxidase and malonyldialdehyde activities as determinants of oxidative stress. In relaxin-treated liver tissue, spectrophotometry showed a better oxygen supply and decreased myeloperoxidase and malonyldialdehyde activities. Our data suggest that relaxin can influence the oxygen distribution in liver tissue and reduce cell damage caused by IRI.

引用

页码：320 / 321

页数：2

共 2 条

[1]

Relaxin as an additional protective substance in preserving and reperfusion solution for liver transplantation, shown in a model of isolated perfused rat liver [J].

Boehnert, MU ;

Hilbig, H ;

Armbruster, FP .

RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE, 2005, 1041 :434-440

[2]

Imaging of dynamic alteration of functional structures [J].

Singer, M ;

Kessler, M ;

Boehnert, M .

FUNCTIONAL MONITORING AND DRUG-TISSUE INTERACTION, 2002, 4623 :308-313

← 1 →