Blood substitutes based on nanobiotechnology

被引：60

作者：

Chang, Thomas Ming Swi

机构：

[1] McGill Univ, Fac Med, Dept Physiol, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Fac Med, Dept Med & Biomed Engn, Montreal, PQ H3G 1Y6, Canada

来源：

TRENDS IN BIOTECHNOLOGY | 2006年 / 24卷 / 08期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/j.tibtech.2006.06.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Stimulated by concerns of potential infective agents in donated blood, commercial enterprises have attempted to develop blood substitutes since the 1900s. After several years of development, a few of the many leads are showing promise. In this article, nanobiotechnological approaches that are now in phase III clinical trials are reviewed, followed by a discussion of how important basic knowledge gained is being used to develop new generations of blood substitutes based on nanobiotechnology.

引用

收藏

页码：372 / 377

页数：6

相关论文

共 45 条

[1] Oxygen therapeutics: Can we tame haemoglobin? [J].

Alayash, AI .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (02) :152-159

[2] Resuscitative effects of polynitroxylated αα-cross-linked hemoglobin following severe hemorrhage in the rat [J].

Buehler, PW ;

Mehendale, S ;

Wang, HS ;

Xie, JT ;

Ma, L ;

Trimble, CE ;

Hsia, CJC ;

Gulati, A .

FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (08) :764-774

[3]

BURHOP KE, 2001, ARTIF CELL BLOOD SUB, V29, P101

[4]

Chang T.M.S., 1972, Artificial Cells

[5] Future generations of red blood cell substitutes [J].

Chang, TMS .

JOURNAL OF INTERNAL MEDICINE, 2003, 253 (05) :527-535

[6] Therapeutic applications of polymeric artificial cells [J].

Chang, TMS .

NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (03) :221-235

[7] SEMIPERMEABLE MICROCAPSULES CONTAINING CATALASE FOR ENZYME REPLACEMENT IN ACATALASAEMIC MICE [J].

CHANG, TMS ;

POZNANSKY, MJ .

NATURE, 1968, 218 (5138) :243-+

[8] Artificial cell bioencapsulation in macro, micro, nano, and molecular dimensions: Keynote lecture [J].

Chang, TMS .

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY, 2004, 32 (01) :1-23

[9] Analysis of polyethylene-glycol-polylactide nano-dimension artificial red blood cells in maintaining systemic hemoglobin levels and prevention of methemoglobin formation [J].

Chang, TMS ;

Powanda, D .

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY, 2003, 31 (03) :231-247

[10]

Chang TMS, 1998, TISS ENG, P216

← 1 2 3 4 5 →